An invitation to reunite with her estranged Oglala Lakota family launches a grieving young woman (Lily Gladstone) on an unexpected road trip from the Midwest toward the Texas-Mexico border. In this largely solitary journey with an unknown destination, Tana navigates the complex, post-2016 election social climate, and a natural landscape that is increasingly surreal. Along the way, she bonds with unexpected people that are as much a part of the landscape as the mountains and roads. At times at ease, at times on edge as a woman traveling alone, familiar faces and strangers shape her journey as she grapples with the pain of her recent loss and seeks to understand her place in the world.